Arthrotec 50 is a white tablet which contains two active ingredients - diclofenac and misoprostol. Diclofenac belongs to a group of medicines called NSAIDs - Non-Steroidal Anti-Inflammatory drugs. Diclofenac works by relieving the pain and swelling of rheumatoid arthritis and osteoarthritis. However, diclofenac can also reduce the amount of natural protective substances in the stomach lining called prostaglandins. This can cause stomach upset or ulcers. This is where the misoprostol comes into work. Misoprostol is very similar to the natural substance in the stomach so can it help protect from stomach upset or ulcers.
Arthrotec 50 should be kept out of sight and reach of children. It should be stored in its original packaging and should not be stored over 25 degrees Celsius.
When using Arthrotec 50, you should follow the instructions given to you by the doctors. The usual dose given for arthritis treatment is one tablet to be taken two or three times a day. The tablets should be swallowd whole - not chewed - and with a drink of water, during or after meals.
If you take more tablets than recommended by your doctor, you should speak to your doctor, pharmacist or hospital as soon as possible, taking your medicine with you. If you forget to take a dose, do not double up doses. Take the dose as soon as your remember and then take the next dose at the correct time.
Arthrotec 50 contains two active ingredients - Diclofenac Sodium and Misoprostol. The other ingredients are lactose monohydrate, microcrystalline cellulose, corn starch, povidone, magnesium stearate, methylacrylic acid copolymer type C, sodium hydroxide, talc, triethyl citrate, hypromellose, crospovidone, hydrogenated castor oil and colloidal silicon dioxide.
Arthrotec 50 should not be taken if you are allergic to any of the ingredients in the medicine, other NSAIDs such as aspirin or other prostaglandin medicines. You should not take this medicine if you currently have an ulcer or hole in your stomach or intestines, if you currently suffer from bleeding in your stomach, intestines or brain, if you are undergoing or have just had coronary artery bypass graft surgery, if you have severe kidney or liver failure, have established heart disease and/or cerebrovascular disease or if you have or have had problems with your blood circulation.
You should speak to your doctor before taking Arthrotec if you smoke, if you have diabetes, if you have angina, blood clots, high blood pressure, raised cholesterol or raised triglycerides, if you have other health problems such as liver or kidney disease, if you have previously had stomach ulcers or bleeding in the stomach or intestines, if you bleed or bruise easily, if you have inflammation of the intestines,if you have or have ever had asthma or an allergic disease, if you have an infection, if you are dehydrated or if you are over the age of 65.
You should make sure to mention if you are taking any other medicines, including medicines obtained without a prescription. You should make sure to mention if you are taking these medicines especially as they may effect how Arthrotec works, or vise versa: aspirin or other NSAIDs, medicines used to treat arthritis, diuretics, ciclosporin or tacrolimus, lithium, digoxin, warfarin or other oral anticoagulands, medicines used to treat anxiety and depression, medicines used to control your blood sugar, methotrexate, steroids, medicines for high blood pressure, magnesium containing antacids, quinolone antibiotics, ketoconazole and if you have taken a medicine called mifepristone within the last 12 days.
If you are pregnant, think you may be pregnant or breast-feeding, you should not take Arthrotec.
As with all medicines, Arthrotec can cause side effects, although not everybody gets them. You should stop using Arthrotec immediately if you notice any signs of an allergic reaction. You should stop taking Arthrotec immediately and contact your doctor if you get severe stomach pains or you notice any sign of bleeding or rupture in the stomach or intestines, or if you have jaundice. Other side effects include stomach ache, diarrhoea, nausea, indegestion, rash, itching, vomiting, wind, constipation, burping, gastritis, ulcers in the stomach or intestines, headahce, dizziness, difficulty sleeping, changes in blood tests relating to the liver, swelling of the mouth, abnormal or unexpected bleeding from the vagina, menstrual disturbances, reduction in the number of blood platelets, purpura, urticaria, inflammation of the liver, severe liver disorders including liver failure, heart failure, chest pain, palpitations, damage to the gullet, worsening of ulcerative colitis or Crohn's disease, kidney or liver problems, shortness of breath, seizures, symptoms of meningitis, fever, loss of consciousness, fluid build up in the body that can cause swollen ankles and legs, vomiting blood, psychotic reactions, swelling of the tongue, mouth ulcers, dry mouth, depression, feeling anxious, mood swings, irritability, memory problems, feeling confused, feeling shaky, nightmares, drowsiness, tiredness, difficulty seeing, impaired or blurred vision, ringing in the ears, changes in the way things taste, chills, fever, increased sensitivity to light, inflammation, loss of appetite, abnormal contractions of the womb, rupture in the womb, retained placenta after giving birth, clotting in the amniotic fluid, bleeding in the womb, miscarriage, death of the unborn baby, birth defects, premature birth, low blood pressure, high blood pressure, reduction in the number of white blood cells and anaemia.
If any of these side effects get serious, or you get side effects not listed above, please speak to your doctor or pharmacist.
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