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As part of the Frosts Pharmacy Group, a family run business established in 1925 by John Frost and now run by his grandson Stuart Gale, we are a fully registered UK pharmacy and adhere to the standards set by the General Pharmaceutical Council. We run successful high street pharmacies in Banbury and Oxford, in the UK, as well as our online chemist services.

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  2. Cystitis Treatment & Relief
  3. Nitrofurantoin 100mg 6 capsules Macrobid Prolonged release for UTI
Nitrofurantoin 100mg 6 capsules Macrobid Prolonged release for UTI

Nitrofurantoin 100mg 6 capsules Macrobid Prolonged release for UTI

£ 19.99
This product is currently out of stock.

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  • 3 day course for female patients with a UTI / Cystitis
  • One capsule to be taken TWICE a day for 3 days
  • Call NHS111 for out of hours advice if you become ill or your symptoms worsen as these antibiotics will not be dispatched over the weekend if ordered after 3pm on a Friday
  • Ttreats infections of the bladder, kidney and other parts of the urinary tract
  • For treatment of women only - men with these symptoms need to see your GP or call NHS111
  • Not for other infections - please consult your GP
  • For Dental Infections please consult your dentist

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  • Product Information
  • Directions for Use
  • Ingredients
  • Warnings & Side Effects

Nitrofurantoin is an antibiotic drug used to treat Urinary Tract Infections (UTIs), including cystitis and kidney infections.

The dose should be taken with food or milk (e.g. at meal times). One capsule TWICE a day for 3 days.

Excipients: Lactose 194.60mg per capsule

acrive ingredient: Nitrofurantion 100mg pro-longed release

Not suitable for patients with

Hypersensitivity to nitrofurantoin, other nitrofurans or to any of the excipients listed above

• Patients suffering from renal dysfunction with an eGFR below 45 ml/minute.

• G6PD deficiency

• Acute porphyria.

Nitrofurantoin is not effective for the treatment of parenchymal infections of a unilaterally functioning kidney. A surgical cause for infection should be excluded in recurrent or severe cases.

Nitrofurantoin may be used with caution as short-course therapy only for the treatment of uncomplicated lower urinary tract infection in individual cases with an eGFR between 30-44 ml/min to treat resistant pathogens, when the benefits are expected to outweigh the risks.

Since pre-existing conditions may mask hepatic or pulmonary adverse reactions, nitrofurantoin should be used with caution in patients with pulmonary disease, hepatic dysfunction, neurological disorders and allergic diathesis.

Peripheral neuropathy and susceptibility to peripheral neuropathy, which may become severe or irreversible has occurred and may be life threatening. Therefore, treatment should be stopped at the first signs of neural involvement (paraesthesia).

Nitrofurantoin should be used with caution in patients with anaemia, diabetes mellitus, electrolyte imbalance, debilitating conditions, and vitamin B (particularly folate) deficiency.

Acute, subacute and chronic pulmonary reactions have been observed in patients treated with nitrofurantoin. If these reactions occur, nitrofurantoin should be discontinued immediately.

Chronic pulmonary reactions (including pulmonary fibrosis and diffuse interstitial pneumonitis ) can develop insidiously, and may occur commonly in elderly patients. Close monitoring of the pulmonary conditions of patients receiving long-term therapy is warranted (especially in the elderly).

Urine may be coloured yellow or brown after taking Nitrofurantoin. Patients on Nitrofurantoin are susceptible to false positive urinary glucose (if tested for reducing substances).

Nitrofurantoin should be discontinued at any signs of haemolysis in those with suspected glucose-6-phosphate dehydrogenase deficiency.

Gastrointestinal reactions may be minimised by taking the drug with food or milk, or by adjustment of dosage.

Hepatotoxicity

Hepatic reactions, including hepatitis, autoimmune hepatitis, cholestatic jaundice, chronic active hepatitis, and hepatic necrosis, occur rarely. Fatalities have been reported. The onset of chronic active hepatitis may be insidious, and patients should be monitored periodically for changes in biochemical tests that would indicate liver injury. If hepatitis occurs, the drug should be withdrawn immediately and appropriate measures should be taken.

For long term treatment monitor the patient closely for appearance of hepatic or pulmonary symptoms and other evidence of toxicity.

Discontinue treatment with nitrofurantoin if otherwise unexplained pulmonary, hepatotoxic, haematological or neurological syndromes occur.

Authored on 22 November 2021

Robert Bradshaw

Robert Bradshaw - MRPharms BSc(Hons) Pharmacy

Pharmacist Manager & Lead Clinical Pharmacist

GPhC Number: 2036118

Reviewed on 22 November 2021

Stuart Gale

Stuart Gale - BSc (hons) MRPharmS

Superintendent Pharmacist and Owner

GPhC Number: 2039889

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9 July 2019
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