Mysimba Weight Loss Treatment
Mysimba is a weight loss tablet that works by suppressing your appetite in people with a body mass index (BMI) of over 30, or those with a BMI of 28-30 with at least one comorbidity.
Mysimba comes in the form of prolonged-release tablets containing 7.2 mg naltrexone and 78 mg bupropion. These medicines are released from the weight loss pills gradually over a few hours.
Mysimba weight loss is a tablet alternative to Saxenda and is ideal if you want an appetite suppressant but do not like injecting medicine.
Buying Mysimba Online in the UK
You can get Mysimba online at Oxford Online Pharmacy from £109.98* with a free online doctor's assessment and private prescription.
Can I buy Mysimba over the counter?
Mysimba is licenced as a prescription-only medicine, which means that it is not available over the counter, and you will need a valid UK prescription. One of our online doctors can issue this prescription – start the weight loss consultation now.
Alternatively, there are over-the-counter (pharmacy) weight loss aids that are available without a prescription, such as Orlos, Alli and XLS Medical. For our full range of weight loss aids click here.
Can I get Mysimba on the NHS?
Mysimba tablets are not yet available through the NHS, however, they remain available for weight loss treatment via private prescription from Oxford Online Pharmacy.
Using our online doctor service one of our GMC registered doctors will assess your suitability for the medicine and could issue a free-of-charge private prescription, you will only be required to pay for the tablets.
Is Mysimba suitable for me?
Mysimba tablets are prescribed as an aid for individuals with a body mass index (BMI) of over 30, or those with a BMI of 28-30 and suffering from other risk factors, such as diabetes.
You should always check the patient information leaflet or speak to a pharmacist or doctor regarding your suitability for the medication as there will likely be some contraindications.
You should not use Mysimba if:
- You are aged 75 or over.
- You have an allergy to naltrexone, bupropion, or any other components of this medicine.
- You suffer from uncontrolled high blood pressure (hypertension) that is not effectively managed with medication.
- You have a history of seizures (fits) or currently have a condition that causes seizures.
- You have been diagnosed with a brain tumour.
- You are a heavy drinker and have recently quit drinking alcohol or plan to do so while taking Mysimba.
- You have recently stopped taking sedatives or anxiety medications, especially benzodiazepines, or plan to discontinue them while using Mysimba.
- You have experienced or been diagnosed with bipolar disorder, characterised by extreme mood swings.
- You are taking other medications containing bupropion or naltrexone concurrently.
- You have a current or history of an eating disorder, such as bulimia or anorexia nervosa.
- You are presently dependent on chronic opiates or opiate agonists, like methadone, or are undergoing acute withdrawal (cold turkey).
- You are using medications for depression or Parkinson's disease known as monoamine oxidase inhibitors (MAOIs), or you have used them within the last 14 days.
- You have severe liver disease.
- You have reached the end stage of kidney disease.
BMI weight loss calculator
The BMI calculation involves dividing an adult's weight in kilograms (kg) by the square of their height in meters (m). To illustrate, if your weight is 70 kg (approximately equivalent to 11 stone) and your height is 1.73 meters (approximately 5 feet 8 inches), you can determine your BMI as follows:
Square your height: 1.73 x 1.73 = 2.99.
Divide 70 by 2.99, resulting in a BMI of 23.41.
Some people find it easier to work out on a calculator and these days there are a lot of good tools online to do this, such as the NHS BMI calculator.
How does Mysimba work?
Mysimba contains two active ingredients: naltrexone and bupropion. Both medications target the reward pathways in the brain, aiming to suppress hunger and cravings for food. Bupropion functions by reducing appetite, while naltrexone is believed to help control cravings.
While these medications are not new, this is the first instance of them being combined in a single tablet.
Other weight loss aids available at Oxford Online Pharmacy are:
Many people ask whether it is worth taking more than one weight loss aid at once, to speed up results. Such as Orlistat tablets, a medicine that binds some of the fat from the food you eat and Mysimba appetite suppressant tablets. So, can you take Mysimba and Orlistat together?
The short answer is no, taking both medicines at the same time will not result in faster weight loss. By doing this you could increase your chances of worse and more intense side effects which can potentially result in discontinuing both medicines altogether.
Don’t hesitate to contact one of our pharmacists if you do not think that your weight loss medicine is effective on its own as we may be able to offer a more suitable, alternative option for you.
For more information head over to our weight loss page.
*These prices are as of 12.09.23 and are subject to change.
How to take Mysimba?
Mysimba dosing schedule:
- Week 1: Take one tablet in the morning.
- Week 2: Take one tablet in the morning and one tablet in the evening.
- Week 3: Take two tablets in the morning and one tablet in the evening.
- Week 4 and onwards: Take two tablets in the morning and two tablets in the evening.
The maximum daily dose of Mysimba is two tablets, taken twice daily.
After 16 weeks of treatment, you should have lost 5% of your total body weight.
How long does Mysimba take to work?
Mysimba will start to work straight away, however, you may only start to notice the full effects after a few weeks.
This medicine can be taken for as long as you require if you have lost 5% or more of your body weight and see substantial Mysimba results by week 16 of treatment. If you fail to lose at least 5% of your body weight after 16 weeks on Mysimba, the treatment may be deemed unsatisfactory, and your doctor will discontinue the treatment.
Do not worry if this is the case, there are plenty of other weight loss treatments that you can try and our GPhC registered pharmacists will discuss the alternative options with you.
How long does Mysimba last?
Mysimba will last for as long as you are taking it. A single pack of 112 tablets lasts 5 weeks when you initially start Mysimba. We recommend that you take your medication as directed. When you use Mysimba, your dose will be gradually increased over four weeks until you reach the maintenance level.
How effective is Mysimba?
Mysimba before and after
Research indicates that obese adults who shed 5-10 per cent of their body weight can experience significant enhancements in their physical and mental well-being. Combining Mysimba with a regular exercise routine and a nutritious diet makes it possible to achieve a weight loss of up to 15 per cent. (1)
To ensure the best weight loss results, it is crucial to closely adhere to the instructions provided by your healthcare provider when using Mysimba. Failing to do so may lead to adverse effects.
Mysimba weight loss reviews
Due to this being a new product to the UK market, there are not many Mysimba reviews available, however, you can refer to the US site, Contrave to view some of the Mysimba success stories.
Mysimba Side Effects
The most frequently observed side effects associated with Mysimba (experienced by more than 1 in 10 individuals) include nausea and vomiting (feeling and being sick), as well as constipation. Dizziness and dry mouth were also commonly reported (seen in up to 1 patient in 10). For a comprehensive list of all reported side effects related to Mysimba, please refer to the package leaflet.
Certain patients who are at higher risk of experiencing side effects should not use Mysimba. This includes individuals with severely impaired kidney or liver function, those with uncontrolled high blood pressure, a history of seizures (fits), specific psychological conditions, brain tumours, or undergoing alcohol or drug withdrawal. For a detailed list of restrictions, please consult the package leaflet.
While experiencing side effects are unlikely, there is a chance of experiencing them when taking any medication. If you have any worrying side effects or side effects that won't go away, get in touch with one of our healthcare professionals.
Common side effects:
- Hot flushes
- Nausea or vomiting
- Taste changes
- Changes in blood pressure
- Hair loss
Uncommon side effects:
- Abnormal dreams, agitation, and mood swings
- Balance disorders
- Motion sickness
- Abdominal discomfort
- Burping or belching
- Increase in hepatic enzymes
- Gallbladder inflammation
- Changes in kidney blood tests
- Erectile dysfunction
- Increased thirst and appetite
- Urticarial skin rash
Rare side effects:
- Jaw pain
- Irregular menstruation
- Chest pain
- Blood and lymphatic system disorders
- Loss of consciousness
- Lip swelling and toothache
- Bleeding from the rectum
- Abdominal pain
- Changes in urinary frequency
- Vaginal dryness, bleeding, and alterations in menstrual patterns
How long do Mysimba side effects last?
Like most medicines, there is a possibility you will experience some side effects when you start taking Mysimba, normally, the common side effects shouldn’t continue for more than a few weeks.
If your symptoms last longer than two weeks, get in touch with a member of our team who will be able to help.
What to do if you experience side effects?
If you are experiencing consistent bothersome side effects, get in touch with one of our pharmacists who may adjust your dose or suggest an alternative treatment.
If you experience any of the rare side effects, we suggest you stop taking the Mysimba tablets and get in touch with us as soon as possible.
Mysimba and pregnancy
Mysimba should not be used during pregnancy, in women who are planning to get pregnant, or in women who are breast-feeding.
If you are pregnant or breastfeeding, suspect you may be pregnant, or plan to have a baby, consult a doctor or pharmacist before using this medication.