Mysimba Tablets (90mg)

Avoid using Mysimba in conjunction with the following medications: 

1. Monoamine oxidase inhibitors (used to treat depression or Parkinson's disease), such as phenelzine, selegiline, or rasagiline. You must discontinue these drugs for at least 14 days before starting Mysimba (refer to "Do not take Mysimba"). 
2. Opiates and medications containing opiates, such as those for coughs and colds (e.g., mixtures containing dextromethorphan or codeine), opiate addiction treatment (e.g., methadone), pain relief (e.g., morphine and codeine), and diarrhoea (e.g., paregoric). You must cease using any opiate medications at least 7-10 days before initiating Mysimba. Your doctor may conduct a blood test to ensure that your body has eliminated these medications before commencing your treatment. Naltrexone blocks opiate effects, and if you take higher doses of opiates to counteract naltrexone's effects, you may experience life-threatening acute opiate intoxication. After discontinuing Mysimba treatment, you may become more sensitive to low opiate doses (see "Do not take Mysimba").

Inform your physician if you are taking any of the following medications, as your doctor will closely monitor you for potential side effects:

• Medications that may increase the risk of seizures when used alone or in combination with naltrexone/bupropion, including:
  • Medications for depression and other mental health conditions.
  • Steroids (excluding eye and skin preparations or inhalers for respiratory conditions like asthma).
  • Malaria prevention drugs.
  • Quinolones (antibiotics such as ciprofloxacin for treating infections).
  • Tramadol (an opiate painkiller).
  • Theophylline (used for asthma treatment).
  • Sedating antihistamines (e.g., chlorphenamine, used to manage allergies).
  • Blood sugar-lowering medications (e.g., insulin, sulphonylureas like glyburide or glibenclamide, meglitinides like nateglinide or repaglinide).
  • Sleep aids (sedatives like diazepam).
• Medications for depression (e.g., amitriptyline, desipramine, imipramine, venlafaxine, paroxetine, fluoxetine, citalopram, escitalopram) or other mental health conditions (e.g., risperidone, haloperidol, thioridazine). Mysimba may interact with some depression medications, potentially causing serotonin syndrome, characterized by symptoms like mental status changes (e.g., agitation, hallucinations, coma), elevated body temperature above 38°C, increased heart rate, unstable blood pressure, exaggerated reflexes, muscular rigidity, lack of coordination, and gastrointestinal symptoms (e.g., nausea, vomiting, diarrhoea).
• Certain blood pressure medications (beta-blockers like metoprolol and centrally acting antihypertensive like clonidine).
• Medications for irregular heart rhythms (e.g., propafenone, flecainide).
• Medications for cancer treatment (e.g., cyclophosphamide, ifosfamide, tamoxifen).
• Medications for Parkinson's disease (e.g., levodopa, amantadine, or orphenadrine).
• Ticlopidine or clopidogrel, primarily used for heart disease or stroke treatment.
• HIV infection and AIDS medications (e.g., efavirenz and ritonavir).
• Epilepsy medications like valproate, carbamazepine, phenytoin, or phenobarbital. Your doctor may need to adjust the dosages of these medications or Mysimba and closely monitor you for potential side effects.

Mysimba may reduce the effectiveness of other medications when taken concurrently, particularly if you are using digoxin for heart treatment. If this applies to you, inform your doctor, as they may consider modifying the dosage.

No, Mysimba is a prescription-only medicine in the UK and should only be bought from a safe and reputable clinic or pharmacy.

You might be able to, but these medicines are not used for weight loss when alone, only as part of the combination medicine Mysimba.

Taking Mysimba results in a smaller appetite, meaning you eat less, but it is not classed as an appetite suppressant.

We do not recommend drinking alcohol while taking Mysimba. Mysimba and alcohol do not mix and can make you unwell.

No, you should not use more than one medicine to help you lose weight at any time.

Yes, Contrave is the brand name for Mysimba in the USA and some other parts of the world. The medicine, strength and even the manufacturer of Contrave and Mysimba are the same. It is normal for medicines to have different brand names in different parts of the world.

Use of Mysimba and alcohol in excess may raise the chance of fits (seizures), mental disorder episodes, or reduced alcohol tolerance.  

Your doctor may advise you to abstain from drinking or drink as little as possible while taking Mysimba. If you are drinking heavily now, do not quit suddenly, as this may put you in danger of having a seizure. 

Mysimba 

Mysimba tablets constitute a weight loss medication comprising two active components: naltrexone and bupropion. 

These ingredients are commonly used to assist individuals in managing withdrawal symptoms from addictive substances and mitigating cravings. 

The mechanism of action is believed to involve influencing the region of your brain responsible for regulating food consumption and the body's reactions to cravings. 

In this manner, Mysimba is believed to facilitate adherence to a calorie-controlled diet, simplifying the process of weight loss. 

Saxenda

Saxenda is a weight loss medication administered through self-injections daily. 

It includes Liraglutide as the active ingredient, categorized as a GLP-1 receptor agonist. 

Another medication within this same category is Semaglutide, available in Wegovy. 

These drugs function by engaging with your hunger-related hormones, diminishing your appetite, and prolonging the feeling of fullness. This, in turn, simplifies your ability to adhere to a controlled-calorie diet. 

Mysimba vs Saxenda 

Saxenda can potentially help you achieve a 5% weight loss milestone approximately four weeks faster than Mysimba. However, it's essential to understand that this doesn't automatically make it the superior treatment choice for you. 

During your initial online consultation, our GMC registered doctors will assess numerous factors to determine the most suitable weight loss medication for you. The speed at which you may shed pounds is just one element in this evaluation. 

We will also consider your overall health and any medical conditions that might make one treatment more suitable for you than the other. For instance, you might have an allergy to a specific ingredient in one of these treatments but not in the other. Alternatively, if you have a fear of needles, Mysimba might be the preferred option for you. 

Furthermore, your provider will consider the potential side effects associated with each medication, especially if you've had prior experiences with similar drugs. 

At Oxford Online Pharmacy you can get 6 weeks’ worth of Mysimba tablets for only £119.98*. compared to Saxenda injections which cost £50* per pen, when you start using Saxenda a pen will last 17 days. 

*These prices are as of 12.09.23 and subject to change.

Mysimba possesses the capability to promote weight loss, and it is anticipated that individuals should attain a minimum decrease of 5% from their initial body weight within a span of 16 weeks while using the medication. 

If the 5% weight loss goal has not been achieved within the designated 16-week timeframe, it is possible that your healthcare provider may contemplate discontinuing the use of Mysimba, as it may not be the most appropriate treatment option for your needs. 

As you can see from the comparison, Mysimba tablets could be a great weight loss alternative for those who want to suppress hunger but do not want to use an injection to do this. 

You can buy Mysimba in the UK online from Oxford Online Pharmacy, once you’re on the website, select the Mysimba tablets from the weight loss category. Then you will be prompted to answer a short questionnaire for our online doctors who will then assess your suitability for the treatment. This is to ensure safe prescribing so we can find the best treatment for you.  

You may want to look at our other weight loss aids such as Saxenda injections or Orlistat tablets, you can find more information about these here.  

Don’t hesitate to get in touch if you are still unsure after reading this article or have any questions for a member of our trained healthcare team. Contact us at 01295 262925 alternatively, you can email us at help@oxfordop.co.uk. 

Clinical trials have demonstrated promising outcomes for Mysimba.

Mysimba has the potential to facilitate weight loss, and it is expected that you should achieve a minimum reduction of 5% from your initial body weight within 16 weeks of taking the medication.

If, however, you have not reached the 5% weight loss target within the 16-week period, your healthcare provider may consider discontinuing Mysimba as it may not be the most suitable treatment option for you.

Nevertheless, there is no need to worry, as there are alternative weight loss treatments available such as Saxenda and Orlistat, which may be more compatible with your needs and goals.

When combined with a balanced diet, Mysimba can help to boost weight loss for people with a BMI of over 30, or those who have a BMI of 28-30 and who suffer from other risk factors, such as diabetes.

You must always make sure you inform us of any medicine you are currently on before taking a new medicine so we can provide the best and safest option for you.

Mysimba tablets are not yet available through the NHS, however, they remain available for weight loss treatment via private prescription from Oxford Online Pharmacy. You can find more information on NHS obesity treatments here. 

The simultaneous use of Mysimba and Saxenda should only be considered under the supervision and guidance of a healthcare professional. Although both medications are prescribed for weight management, they operate through distinct mechanisms and carry their own potential side effects. 

Mysimba contains naltrexone and bupropion, while Saxenda contains liraglutide. These medications have different modes of action within the body. Combining them may increase the risk of certain side effects or interactions between the drugs. Therefore, it is crucial to consult with your healthcare provider to assess the potential benefits and risks of using Mysimba and Saxenda together, considering your medical history and individual needs. Your healthcare provider will be able to offer personalised advice and guidance in this instance.