What are Trimix injections

Men use Trimix injections to treat erectile dysfunction when oral treatments are not suitable or haven’t been fully effective.

Having erectile dysfunction means that you cannot produce an erection firm or long enough to enjoy sex. This might not be every time.

Men who experience unsatisfactory erections often want expert advice and treatment on this sensitive subject, although many find it difficult to talk about with their GP face to face.

Online pharmacies and clinics have become really valuable to those looking to treat their ‘embarrassing issues’. With GMC-registered doctors, online pharmacies offer online consultations and, after a doctor's review, can prescribe medicines, similar to Trimix, for erectile dysfunction (ED).

Common treatments for erectile dysfunction include Viagra, Sildenafil and Tadalafil, along with other oral, cream and injectable treatments available to purchase online via an online pharmacy.

These tablets are effective at helping the majority of men who suffer from erectile dysfunction and are usually recommended as a first-line treatment.

If the oral medicines are not effective at helping you achieve and maintain an erection, you could consider other treatment options, such as erectile dysfunction injections like Trimix, Invicorp, Caverject or Viridal Duo.

What are Trimix injections UK?

Trimix is a medically prescribed injection for erectile dysfunction (ED). It contains three active ingredients: alprostadil, papaverine, and phentolamine.

Trimix comes in different forms, such as a topical Trimix gel and injectable Trimix shots that are given as an intracavernosal injection at the side of the penis.

Trimix is beneficial for cases of erectile dysfunction where tablets do not work.

Using ED injections also prevents systematic side effects experienced with oral ED medications.

How do Trimix injections work?

TriMix gets its name from being a compounded medication that combines three drugs: phentolamine, papaverine, and alprostadil.

Alprostadil is a vasodilating prostaglandin that enhances blood flow by relaxing the smooth muscles in the penile blood vessels.

Papaverine works by relaxing the muscle, promoting increased blood flow to the penis.

Phentolamine is an alpha-blocker that relaxes the muscles in blood vessels, helping a better blood flow to the penis.

How to use Alprostadil injections

The dosage required varies from person to person, so you must always follow the advice from your doctor, which will be displayed on the prescribing label of your medicine.

It can take between 5 - 20 minutes for the treatment to start working, so it is advised you wait at least 10 -30 minutes before you have sexual intercourse.

You should be able to get and maintain an erection for about an hour after the medicine has started working.

These injections should be used no more than three times in one week. Before injecting again, you must wait at least 24 hours after your last injection.

Alprostadil self-injection Instructions

You should always use any medicine as directed by your healthcare provider. To use ED injections, you should follow these steps:

1. Start by thoroughly washing your hands and gathering the required items: the medicine vial, an alcohol pad, and a syringe.
2. Use the alcohol pad to clean the rubber top of the vial.
3. Pull back the syringe plunger to your specified dose to fill it with air, then insert the needle into the vial and push the air in.
4. Invert the vial and gently pull back the plunger to draw the correct dose of medication.
5. Tap the syringe to remove the air bubbles, then remove the needle and replace the cap.
6. To give the injection, select a suitable spot on the side of the penis, avoiding the centre and any visible veins.
7. Clean the area with an alcohol pad, then insert the needle straight in at a 90-degree angle and slowly inject the medication.
8. Once done, withdraw the needle and apply pressure to the injection site for at least one minute to stop any bleeding.
9. Safely dispose of the used syringe in a proper container.

Alprostadil Injection side effects

Like other medicines, side effects can happen, especially if you do not use the medication as directed by your doctor.

Side effects of Alprostadil may include:

• Injection site rash and swelling
• Headaches and feeling dizzy
• Hypertension
• Infections (this is why you need to ensure the area, hand and needle are all sterile)
• Blood at the injection site
• Prolonged erections

Many side effects are often temporary, and they will go over time. Still, if you experience a severe reaction to the treatment, such as priapism (painful, prolonged erections), you should go to your nearest hospital emergency department.

Where to buy Trimix injections UK

Trimix isn't available in the UK; it's not even easily available in the USA. However, there are alternative UK options like Caverject and Viridal, both of which contain the active ingredient alprostadil.

Muse pellets are another form of Alprostadil, these pellets and inserted directly into the head of the penis instead of injected like Caverject and Viridal.

You can get Caverject injections for £29.99 from Oxford Online Pharmacy.

BUY CAVERJECT

Viridal Duo injections are available for £42.99. This offers great value since each pack includes two pens.

BUY VIRIDAL DUO

*Prices as of 02.01.25 and are subject to change.

Trimix FAQs

Can you get Trimix in the UK?

No, it isn't available in the UK. Trimix is a compounded medication primarily made in the US by compounding pharmacies.

If you think you can use Trimix injections, you might be eligible for Caverject or Viridal Duo in the UK.

Head over to our erectile dysfunction treatment page to learn more about the available treatments and see whether they are suitable for you.

If you are unsure, contact a member of our team who will be happy to advise you.

How long does a Trimix injection last?

These injections last for around 60 minutes in your system, so you should be able to get and maintain an erection anytime within this timeframe.

You must not reinject within 24 hours since your last injection.

If you find that this treatment isn’t producing the desired effect, contact your doctor, and they can advise you on the next steps.

Is Trimix stronger than Viagra?

Both Viagra and Trimix injections are effective ED treatments, however, as Trimix is injected directly into the penis, it is faster acting.

What is the downside of Trimix?

The potential side effects are one downside of erectile dysfunction injections, these include painful injection, bruising, bleeding from the injection site, and priapism.

What is the best injection for erectile dysfunction in the UK?

This all depends on your personal preference. Most available erectile dysfunction injections contain the active ingredient Alprostadil, so they work similarly.

Caverject and Viridal Duo are both well-known popular options.

Does Trimix require arousal?

No, Trimix, like other alprostadil-containing injections, helps you get hard for sexual activity without the need for arousal first.

Does Trimix affect the heart?

Arrhythmia is an irregular heart rhythm, which can rarely occur as a side effect of Trimix injections, especially in those with existing cardiac conditions.

Where do you inject Trimix for best results?

Trimix injections should be injected into the side of the base of the penis. Using this injection anywhere else is unsafe.

Is Trimix available over the counter?

No, it is a prescription-only treatment and can only be prescribed by a registered doctor.

Will Trimix increase size?

While these injections can help you achieve and maintain an erection long enough for sex, they do not increase the size of your penis.

References

1. Trimix Injections: Dosage, Instructions & More, Olympia pharmacuticals
2. Erectile Dysfunction: TRIMIX Injections, Utah University
3. Erectile Dysfunction Injections: How to, Risks, and Side Effects, Health line
4. Penile injections for erectile dysfunction (impotence) - Newcastle Hospitals NHS Foundation Trust
5. Alprostadil Injection and Suppository for Erectile Dysfunction, WebMD