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Nystaform HC Cream 30g
Nystaform HC Cream 30g Product information
£19.49
Nystaform HC cream is a prescription-only topical treatment for infected skin conditions where a fungal and/or bacterial infection is present. Common example cases where Nystaform HC cream may be prescribed include Ringworm, Athlete’s Foot and infected nappy rash (1).
This combination cream contains three active ingredients to help fight the infection – an antifungal, an antiseptic and a mild corticosteroid to reduce inflammation. It is prescribed for use for a maximum of seven days. After this time, if there is no improvement, you should seek further medical advice (1).
Product Information for Nystaform HC Cream 30g
What is Nystaform HC Cream and how does it work?
Nystaform HC is a light yellow coloured cream that contains three active ingredients. These are:
Nystatin; an antifungal cream
Chlorhexedine hydrochloride; an antiseptic
Hydrocortisone; a mild corticosteroid
These work in combination to target fungal and/or bacterial infections. The nystatin works by damaging the outer membrane of fungi in fungal infections, stopping them from multiplying and helping to kill them. It is particularly effective against yeast infections. The chlorhexidine hydrochloride is an antiseptic that kills or limits the growth of bacteria on your skin. And hydrocortisone reduces redness, swelling and itching (1).
How does steroid cream help eczema?
Steroid creams are particularly effective at helping to treat eczema as they work by stopping skin cells from releasing inflammatory chemicals that cause inflammation, swelling and itching. This helps to calm the core symptoms associated with eczema. However, while they can help provide relief from the symptoms, they do not cure the underlying condition (2).
What is Nystaform HC Cream used for?
Nystaform HC cream is generally recommended for adults and children who have a fungal and/or bacterial skin infection. A clinician may prescribe Nystaform HC cream for dermatitis or eczema when it is accompanied by symptoms of a fungal and/or bacterial infection, for example weeping, crusting, soreness or extreme redness (1).
If you have previously used Daktacort, this is a suitable replacement.
Complete a clinical eczema consultation where we will help you understand if this is the right treatment for your condition.
Nystaform HC Cream 30g reviews
How to use Nystaform HC Cream 30g
Wash your hands before you start to apply Nystaform HC cream. Apply a thin layer of the cream to cover the affected area. Applying a thicker layer will not help the treatment to work any faster or better.
You should use the cream two or three times per day, or as your prescriber recommends. Do not cover the treated skin with bandages or anything else unless specifically advised to you by your prescriber (3).
How long can I use it for?
Nystaform HC cream should be used for a maximum of seven days (3). If your skin issue has not significantly improved by the end of your course of treatment, seek further medical advice.
What if my symptoms don’t improve, or they do for a while then come back?
Many skin issues happen intermittently. If your symptoms do not improve after using Nystaform HC cream, or they come back shortly after finishing your treatment, you should not just start applying the cream again. Instead, speak to your prescribing team for more advice and support (3).
When to use steroid cream for eczema
You may be prescribed steroid cream to help treat your eczema if your skin is accompanied by signs of a bacterial or fungal infection (2). This can happen because eczema damages the protective barrier of your skin, and when it becomes cracked or broken, either through dryness or scratching, fungi and bacteria can enter and multiply (4).
Eczema also naturally creates an environment in which bacteria and fungi can thrive. For example, eczema often develops in skin folds such as the groin and armpit, which are warm and moist and naturally favour fungal growth (4).
Your prescriber will be able to advise if you should use steroid cream to treat your eczema.
Storage
Store Nystaform HC Cream out of direct sunlight and in temperatures not exceeding 25°C. Keep out of reach of children and vulnerable adults.
The shelf life of Nystaform HC Cream is approximately 2 years. Do not use beyond this point (3).
Side effects of Nystaform HC Cream 30g
Nystaform HC contains benzyl alcohol and cetostearyl alcohol, which may cause localised irritation and mild skin reactions.
If you develop a rash, or your skin becomes itchy, red or swollen where you have used the cream, stop immediately and speak to your prescriber for advice (3).
You should stop using Nystaform HC cream and seek immediate medical help if you experience any symptoms of a systemic (whole body) allergic reaction. These include:
Swelling of your face, lips, tongue or throat.
A red, itchy skin rash that gets progressively worse.
Wheezing or difficulty breathing.
Feeling faint or dizzy.
A strange, metallic taste in your mouth.
Losing consciousness.
If you experience any of these, contact 111/999 for emergency help and support.
You can report any side effects to your doctor or prescriber, including any of those not listed here. You can also report side effects directly via the Yellow Card Scheme.
Warnings and cautions
You should not use Nystaform HC cream if you are allergic to any of the ingredients, including mystatin, chlorhexidine and hydrocortisone. A full list of the ingredients contained within the medication can be found on the Patient Information Leaflet (PIL).
Nystaform HC Cream is not suitable for tuberculosis skin lesions (3).
If you are pregnant or breastfeeding, always check with your prescriber before using Nystaform HC cream.
Long term or repeated use of Nystaform HC can cause topical steroid withdrawal reactions.
Note for parents/carers on using Nystaform HC cream on infants
Nystaform HC cream may be prescribed to treat infant eczema where fungal or bacterial infection is suspected, or to treat infected skin like that seen in nappy rash. In infants, the cream should only be used under close medical supervision.
Because babies’ skin absorbs medicines more easily, prolonged or widespread use of hydrocortisone creams is not recommended. Parents/carers should avoid using tight dressings, including nappies, over treated skin, and seek advice if the rash worsens, spreads or does not improve within a week (1).
Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)
Nystaform HC Cream. Summary of Product Characteristics. Leatherhead: electronic Medicines Compendium; 2024 Feb 13 [cited 2026 Sep 22]. Available from: https://www.medicines.org.uk/emc/product/2702/smpc
NHS. Hydrocortisone for skin: steroid for skin conditions [Internet]. nhs.uk. 2024 [cited 2026 Sept 22]. Available from: https://www.nhs.uk/medicines/hydrocortisone-for-skin/
Nystaform HC Cream. Package leaflet: information for the user. Norwich: Typharm Ltd; 2024 Jan [cited 2026 Sep 22]. Available from: https://www.medicines.org.uk/emc/files/pil.2702.pdf
The Human Skin Microbiome and its Changes in Atopic Dermatitis [Internet]. National Eczema Association. 2021 [cited 2026 Sept 22]. Available from: https://nationaleczema.org/blog/microbiome-and-atopic-dermatitis/
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Authored on October 7, 2026
Robert Bradshaw (Pharmacist) — MRPharms BSc(Hons) Pharmacy
Superintendent Pharmacist
GPhC Number: 2036118
Reviewed on October 8, 2026