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Hormone Replacement Therapy - HRT
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Blissel Gel Estriol 50mcg vaginal gel 30g Rear view of Blissel Gel Estriol 50mcg vaginal gel 30g

Blissel Gel Estriol 50mcg vaginal gel 30g

Blissel Gel Estriol 50mcg vaginal gel 30g Product information

£34.99

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Product Information for Blissel Gel Estriol 50mcg vaginal gel 30g

Buy Blissel Vaginal gel online in the UK 

The topical hormone replacement therapy product Blissel Vaginal Gel Estriol was created for the treatment of women going through menopause or perimenopause, it contains estriol, a naturally occurring oestrogen hormone that aids in reducing menopause symptoms like vaginal dryness and irritation. Blissel works by replacing the oestrogen which is normally produced in the ovaries.

This gel is simple to use and quickly absorbs into the skin, providing rapid symptom alleviation. It comes in a handy pump dispenser that makes it simple to administer the right amount of gel to the specified region. One pack contains enough medicine for 30 doses. One dose, (applicator filled to the mark), delivers a dose of 1g vaginal gel containing 50mcg of estriol. 

Women who cannot take oral hormone replacement therapy or who prefer a topical treatment option can use Blissel Vaginal Gel Estriol as a safe and efficient treatment for menopausal symptoms of vaginal dryness and irritation. When using this product, it is crucial to adhere to your doctor’s instructions. 

Do not hesitate to get in touch if you have any questions or concerns about using Blissel Vaginal Gel Estriol. Our healthcare professionals can give you further details on the proper application and possible risks of this product. 

Blissel Gel Estriol 50mcg vaginal gel 30g reviews

How to use Blissel Gel Estriol 50mcg vaginal gel 30g

The recommended dose for the first 3 weeks of treatment is one applicator-dose per day, preferably before going to bed. After 3 weeks of use, your discomfort should have decreased, and the dose should be lowered. You may only need one dose twice a week.

Use the applicator to insert the gel in the vagina (it is recommended before going to bed).

Your doctor will aim to prescribe the lowest dose to treat your symptom for as short as necessary. Speak to your doctor if you think this dose is too strong or not strong enough.

The following instructions explain how the gel should be used.

The box contains two different elements consisting of the tube and the applicator (plunger and cannula).

  1. Remove the tube cap, turn it upside down and use the sharp point to pierce the seal on the neck of the tube. Do not use if seal is broken.
  2. Take out a cannula and the plunger. Insert the white plunger all the way into the cannula. Screw the cannula on the neck of tube.
  3. Squeeze the tube to fill the applicator with the gel up to the filling mark. The plunger will stop at the mark.
  4. Unscrew the cannula from the tube and replace the cap on the tube.
  5. To apply the gel, lie down, insert the end of the applicator deep into the vagina and slowly push the plunger all the way down
  6. After use, pull the plunger out of the cannula. Rinse both cannula and plunger well with warm and clean water so it can be reused for the next application.

If you use more Blissel than you should:

  • There is no need to be concerned if gel is accidently ingested or if too much gel is used at one time. Nevertheless, you should seek medical advice.
  • After a few days, you might feel nauseous or be sick, and some women might experience some vaginal bleeding.

If you forget to use Blissel:

  • Never take two doses at once to make up for missed ones.
  • Unless you are more than 12 hours late, take the missed dose as soon as you remember.
  • Simply skip the missing dose if you are more than 12 hours late.
  • Ask your doctor or pharmacist if you have any more questions about the use of this medication.

Side effects of Blissel Gel Estriol 50mcg vaginal gel 30g

This medication may have side effects, however not everyone experiences them. 

Local itchiness or irritation may happen at the start of treatment. Most patients' negative effects subside with continuing usage of the medication. Inform your doctor if any of the following side effects persist or are bothersome, including vaginal bleeding. 

Common side effects (may affect up to 1 in 10 people): 

  • Itching, local irritation in or around the vagina. 

Uncommon side effects (may affect up to 1 in 100 people): 

  • Low abdominal pain, skin irritation, genital rash, headache, Candidiasis (vaginal ‘thrush’) 

The following diseases are reported more often in women using HRT (Hormone Replacement Therapy) medicines which circulate in the blood compared to women not using HRT.  

These risks apply less to vaginally administer treatments such as Blissel: 

  • blood clots in the veins of the legs or lungs (venous thromboembolism) 
  • ovarian cancer 
  • stroke 
  • probable memory loss if HRT is started over the age of 65 

The following side effects have been reported with other HRTs: 

  • gall bladder disease 
  • various skin disorders: 
    • discolouration of the skin especially of the face or neck known as “pregnancy patches” (chloasma) 
    • painful reddish skin nodules (erythema nodosum); 
    • rash with target shaped reddening or sores (erythema multiforme) 
Frequently Asked Questions
References

1.    Cano, A. et al. The therapeutic effect of a new ultra low concentration estriol gel formulation (0.005% estriol vaginal gel) on symptoms and signs of postmenopausal vaginal atrophy: results from a pivotal phase III study. Menopause 19, 1130–1139 (2012).

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Authored on December 29, 2022

Reviewed on December 29, 2022

Stuart Gale (Pharmacist)

Stuart Gale (Pharmacist) - BSc (Hons) MRPharmS

Pharmacist and Owner

GPhC Number: 2039889