Buy Vydura (Rimegepant) Online in the UK
Vydura is the brand name for Rimegepant (pronounced Rim-edgy-pant), a new type of migraine treatment for people who experience migraines with or without aura.
Vydura is a prescription-only medicine and should only be ordered from safe, legitimate online providers like Oxford Online Pharmacy.
Common Causes of Migraines
Migraines are caused by changes in the brain and how it responds to certain things. These changes affect nerve signals, chemicals and blood vessels. Some people are more likely to get migraines because it can run in families.1
There are different things that can trigger a migraine. Triggers are things that can start a migraine or make it more likely to happen.
These include stress, skipping meals and low blood sugar, alcohol, hormonal changes (such as periods or menopause), lack of sleep and the environment you are in (lighting, temperature).
We don’t know exactly why some people experience migraines and others do not, although for many people there is a link to their genes (DNA).2
Our understanding of migraines has grown hugely over the last 20 years, and there is now more research into the condition than ever before.
How Does Vydura Work?
At the start of a migraine, a substance called calcitonin gene-related peptide (CGRP) is released by nerve cells in the brain, this CGRP causes blood vessels in the brain to become wider and cause inflammation.
This inflammation can send pain signals to your brain.
This raised level of CGRP has been shown to cause a migraine and to make it last longer.3
Vydura’s active ingredient, Rimegepant, is a CGRP inhibitor. This means it can block the effects of CGRP.
These CGRP inhibitors help reduce the inflammation, prevent the widening of blood vessels, and ultimately reduce the intensity and frequency of migraines.
It's important to note that CGRP is just one piece of the puzzle when it comes to migraines.
Migraines are complex conditions with many other factors involved, like genetics, hormones, and other chemicals in the brain.
When To Take Vydura
Vydura should be taken at the start of an attack, as early as possible, to treat pain and associated migraine symptoms (e.g. nausea, light/noise/smell sensitivity).
The melt-in-the-mouth wafer-like tablet (oral lyophilisate) should be placed on the tongue or under the tongue. It will disintegrate in the mouth and can be taken without liquid.
If you experience nausea with your migraine, you can take antiemetics (medicines that prevent nausea and vomiting).
Only one tablet of Vydura should only be taken every 24 hours.
Can other Pain Relief be taken with Vydura for Maximum Relief?
Yes, you can use extra pain relief like Paracetamol or Ibuprofen.
Non-medicine remedies like hot/cool pads, TENS machines or essential oils can also be used with Vydura.
Alternative Migraine Medication
Migraines can be treated with pain relief like Paracetamol or Ibuprofen.
Another group of medicines called Triptans can be a suitable treatment if traditional painkillers do not work well, these are usually prescription-only.
Lots of people are prescribed Triptans (most common are Rizatriptan or Sumatriptan) to treat migraines.
Medicines from the Triptan group include;
- Sumatriptan (brand name Imigran) - tablets, nasal spray or injection
- Rizatriptan (brand name Maxalt) - tablets or melt-in-the-mouth wafers
- Almotriptan (brand name Almogran) - tablets
- Zolmitriptan (brand name Zomig) - tablets or melt-in-the-mouth wafers
Triptans work in a different way to Vydura in the brain, causing blood vessels to become narrower and reduce the flow of certain chemicals released during migraines.
Some people cannot take Triptans, such as those with heart related risks, and those who find Triptans ineffective or have had unpleasant side effects.
For those who cannot use Triptans, Vydura is a safe and welcome addition to the treatments available for migraine and is safe to use in people who have heart conditions.
How to use Vydura
Vydura comes in the form of a freeze-dried wafer that can be positioned on or beneath the tongue, where it dissolves.
This medicine works on a neuropeptide so there is no risk of overuse or re-bound headaches.
Acute - if you get fewer than 4 per month: take one tablet when required when you feel migraine is coming on.
For additional guidance on how to use Vydura, please refer to the package leaflet or consult your healthcare professional.
Vydura Side Effects
The most common side effect for Vydura is nausea, which can affect up to 1 in every 10 people.4
Allergic reactions, including difficulty breathing (dyspnea) and severe rash, may affect up to 1 in 100 people.
If you experience any other side effect that you think could be caused by Vydura, it should be reported using the Yellow Card Scheme.
For a full list of potential side effects and limitations associated with Vydura, please refer to the patient information leaflet.