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Vydura (Rimegepant) 75mg 2 oral lyophilisate tablets

£44.99 (£22.50 per tablets)

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	75mg
2 tablets	£44.99
8 tablets	£139.99
16 tablets	£269.99

Buy Vydura (Rimegepant) Online in the UK

Vydura is the brand name for Rimegepant (pronounced Rim-edgy-pant), a new type of migraine treatment for people who experience migraines with or without aura.

Vydura is a prescription-only medicine and should only be ordered from safe, legitimate online providers like Oxford Online Pharmacy.

Common Causes of Migraines

Migraines are caused by changes in the brain and how it responds to certain things. These changes affect nerve signals, chemicals and blood vessels. Some people are more likely to get migraines because it can run in families.1

There are different things that can trigger a migraine. Triggers are things that can start a migraine or make it more likely to happen.

These include stress, skipping meals and low blood sugar, alcohol, hormonal changes (such as periods or menopause), lack of sleep and the environment you are in (lighting, temperature).

We don’t know exactly why some people experience migraines and others do not, although for many people there is a link to their genes (DNA).2

Our understanding of migraines has grown hugely over the last 20 years, and there is now more research into the condition than ever before.

How Does Vydura Work?

At the start of a migraine, a substance called calcitonin gene-related peptide (CGRP) is released by nerve cells in the brain, this CGRP causes blood vessels in the brain to become wider and cause inflammation.

This inflammation can send pain signals to your brain.

This raised level of CGRP has been shown to cause a migraine and to make it last longer.3

Vydura’s active ingredient, Rimegepant, is a CGRP inhibitor. This means it can block the effects of CGRP.

These CGRP inhibitors help reduce the inflammation, prevent the widening of blood vessels, and ultimately reduce the intensity and frequency of migraines.

It's important to note that CGRP is just one piece of the puzzle when it comes to migraines.

Migraines are complex conditions with many other factors involved, like genetics, hormones, and other chemicals in the brain.

When To Take Vydura

Vydura should be taken at the start of an attack, as early as possible, to treat pain and associated migraine symptoms (e.g. nausea, light/noise/smell sensitivity).

The melt-in-the-mouth wafer-like tablet (oral lyophilisate) should be placed on the tongue or under the tongue. It will disintegrate in the mouth and can be taken without liquid.

If you experience nausea with your migraine, you can take antiemetics (medicines that prevent nausea and vomiting).

Only one tablet of Vydura should only be taken every 24 hours.

Can other Pain Relief be taken with Vydura for Maximum Relief?

Yes, you can use extra pain relief like Paracetamol or Ibuprofen.

Non-medicine remedies like hot/cool pads, TENS machines or essential oils can also be used with Vydura.

Alternative Migraine Medication

Migraines can be treated with pain relief like Paracetamol or Ibuprofen.

Another group of medicines called Triptans can be a suitable treatment if traditional painkillers do not work well, these are usually prescription-only.

Lots of people are prescribed Triptans (most common are Rizatriptan or Sumatriptan) to treat migraines.

Medicines from the Triptan group include;

Sumatriptan (brand name Imigran) - tablets, nasal spray or injection
Rizatriptan (brand name Maxalt) - tablets or melt-in-the-mouth wafers
Almotriptan (brand name Almogran) - tablets
Zolmitriptan (brand name Zomig) - tablets or melt-in-the-mouth wafers

Triptans work in a different way to Vydura in the brain, causing blood vessels to become narrower and reduce the flow of certain chemicals released during migraines.

Some people cannot take Triptans, such as those with heart related risks, and those who find Triptans ineffective or have had unpleasant side effects.

For those who cannot use Triptans, Vydura is a safe and welcome addition to the treatments available for migraine and is safe to use in people who have heart conditions.

Vydura (Rimegepant) 75mg 2 oral lyophilisate tablets reviews

How to use Vydura (Rimegepant) 75mg 2 oral lyophilisate tablets

Vydura comes in the form of a freeze-dried wafer that can be positioned on or beneath the tongue, where it dissolves.

This medicine works on a neuropeptide so there is no risk of overuse or re-bound headaches.

Acute - if you get fewer than 4 per month: take one tablet when required when you feel migraine is coming on.

For additional guidance on how to use Vydura, please refer to the package leaflet or consult your healthcare professional.

Side effects of Vydura (Rimegepant) 75mg 2 oral lyophilisate tablets

Vydura Side Effects

The most common side effect for Vydura is nausea, which can affect up to 1 in every 10 people.4

Allergic reactions, including difficulty breathing (dyspnea) and severe rash, may affect up to 1 in 100 people.

If you experience any other side effect that you think could be caused by Vydura, it should be reported using the Yellow Card Scheme.

For a full list of potential side effects and limitations associated with Vydura, please refer to the patient information leaflet.

Frequently Asked Questions

: Vydura could be a good migraine treatment for you to try if you find that medicines from the Triptan group don’t control your migraines well or if you cannot use Triptans.
: Vydura has been approved for use on the NHS in England, Scotland and Wales for treatment of an active migraine but only when other treatments have not worked.
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Vydura has been also been approved by the NHS in England, Scotland and Wales for the prevention of migraine but only when at least 3 other preventative treatments have failed to work or cannot be taken.
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This might be because current treatments for preventing migraine – including beta-blockers, antidepressants and epilepsy medications – can have significant side effects and do not work for everybody.
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Rimegepant is the first oral drug from its class, Gepants, to be approved for migraine treatment in the UK.
: Trials show that Vydura (Rimegepant) is an effective treatment for migraine attacks and preventing frequent migraines.

A study 5 looking at Rimegepant to treat migraines found that after taking the medication:

59% of people experienced pain relief within two hours

21% of people were pain free within two hours

35% of people were free of their ‘most bothersome symptom’ within two hours

42% of people had continued pain relief between two and 48 hours after the first dose

86% of people needed no other pain relief in the first 24 hours

A different study6 looking at Rimegepant as a migraine prevention treatment found that:

People had on average 4.3 fewer monthly migraine days (MMDs)

People had a 50% reduction in their MMDs
: Melt-in-the-mouth tablets (Oral Lyophilisates) get medicine into your body faster than traditional tablets, this means they start working quicker.

Another benefit is that if you experience nausea or vomiting with migraines, there is no chance of the medicine coming back up and therefore not working.
: Gepants, like Vydura, and Triptans work in very different ways to try to control a migraine.

During a migraine, blood vessels in the brain become wider, some people can hear or feel this happen. It’s what causes that throbbing sensation.

Triptans work by making these blood vessels narrow again, reducing the rush of blood to the head which can cause a migraine to last longer or worsen.

Vydura does not cause these blood vessels to narrow, but it does stop them from widening any more.

This makes it a safe option for people who cannot take Triptans because they have heart conditions, these patients can use Vydura.

There are also people who do not respond well or at all to Triptans, this group could benefit from Vydura as it works in a different way.
: We do not recommend you take Vydura during pregnancy or while breastfeeding.
: Early indications suggest that Gepants like Vydura may be the first treatment not associated with medication overuse headache.7

There is ongoing research looking into Gepants as a suitable treatment for those who experience medication overuse headaches or rebound headaches.
: Vydura is suitable for most adults over 18 who have a history of migraines with or without aura.

You’ll be advised against taking Vydura if:

You’re pregnant or breastfeeding

You have a severe liver or kidney condition

You’re allergic to any of the ingredients

You also need to let us know if you’re taking certain medications, as they may impact how well the treatment works, or Vydura may impact how they work.

These treatments include:

Medications for fungal or bacterial infections

Medications to treat HIV

Bosentan – treatment for high blood pressure

St John’s wort

Phenobarbital – treatment for epilepsy

Rifampicin – treatment for tuberculosis (TB)

Modafinil – treatment for narcolepsy
: Sleepiness isn’t a known side effect of Vydura and was not reported in studies of Vydura.

Having a migraine headache itself can make you feel drowsy or sleepy. It can also make you feel tired for a couple of days afterward.
: The first oral Rimegepant treatment approved in the USA, Nurtec, was brought to market as a joint project from pharmaceutical companies Biohaven and Pfizer.

For the European market, Pfizer alone is holding the rights to the product Vydura.
: At the moment the medicine in Vydura, Rimegepant, is under patent. This means that only one medicine company in the UK, Pfizer, is allowed to manufacture it and they set the price.

We are not sure when Vydura will come “off patent” but it is likely to be around 2040.

After this, other companies will be able to manufacture Rimegepant tablets. This increased competition among manufacturers will cause the price to drop, these savings will then be passed on to the customer.
: In the UK, the National Institute for Health and Care Excellence (NICE) and the Scottish Medicines Consortium (SMC) are currently reviewing another medicine from this Gepant group, Atogepant, for treating migraine on the NHS (at time of writing, July 2023).

Other Gepants such as Ubrogepant and Zavegepant might also be considered in the near future.

These drugs are already approved and used widely in the USA.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Vydura (Rimegepant) 75mg 2 oral lyophilisate tablets - Patient Information Leaflet

References

1.   Migraine - NICE Summary, BNF.
2.   Nyholt, D. R., Lea, R. A., Goadsby, P. J., Brimage, P. J. & Griffiths, L. R. Familial typical migraine: linkage to chromosome 19p13 and evidence for genetic heterogeneity. Neurology 50, 1428–1432 (1998).
3.   Edvinsson, L. Role of CGRP in Migraine. Handb. Exp. Pharmacol. 255, 121–130 (2019).
4.   VYDURA 75 mg oral lyophilisate - Summary of Product Characteristics (SmPC) - (emc).
5.   Croop, R. et al. Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial. Lancet 394, 737–745 (2019).
6.   Croop, R. et al. Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial. Lancet 397, 51–60 (2021).
7.   de Vries, T., Al-Hassany, L. & MaassenVanDenBrink, A. Evaluating rimegepant for the treatment of migraine. Expert Opin. Pharmacother. 22, 973–979 (2021).